Translational Cardiology: defining limits and targets at the International Archives of Medicine




Translational research, translational cardiology, definitions, requirements


The Merriam-Webster dictionary reports the first use of “Translational Research†as early as 1986 and the definition given for this term was: “medical research that is concerned with facilitating the practical application of scientific discoveries to the development and implementation of new ways to prevent, diagnose, and treat disease, called also translational medicine†.

The adjective “translational†stems from Classical Latin “translatioâ€, then probably Middle French â€translationâ€, to reach Middle English “translaciounâ€. The idea is to make a transfer from one idiom to another, yet keeping the intimate significance and sense, which is common to language translation methods. It properly stresses the relation to the transfer of scientific knowledge into practical applications. It is obvious how, in less than 30 years, translational research has pervaded all Science domains and how large is the interest of scientists and lay people for this subject


"Translational Research" Merriam-Webster, Available at: Accessed December 15, 2014.

Martínez-Legazpi P, Bermejo J, Benito Y, Yotti R, Pérez Del Villar C, González-Mansilla A, Barrio A, Villacorta E, Sánchez PL, Fernández-Avilés F, del Ãlamo JC. Contribution of the diastolic vortex ring to left ventricular filling. J Am Coll Cardiol 2014; 64: 1711-21.

Landis S. Back to basics: a call for fundamental neuroscience research. Available at: Accessed December 15, 2014.

Editorial. EBioMedicine: Bridging two cultures to improve health. EBioMedicine 2014; 1: 1.

Lauer MS. The basic Science that is Epidemiology. J Am Coll Cardiol Cardiovasc Imag 2014; 7: 879-81.

Glenn C, Goldthwaite MA. The St. Martin’s Guide to Teaching Writing. Boston, MA: Bedford/St. Martin’s. 2008, pp.151–156.

Piras P, Evangelista A, Gabriele S, Nardinocchi P, Teresi L, Torromeo C, Schiariti M, Varano V, Puddu PE. 4D-analysis of left ventricular cycle using Procrustes motion analysis. Plos One 2014; 9(1): e86896. The PLOS ONE Staff. Correction: 4D-Analysis of Left Ventricular Heart Cycle Using Procrustes Motion Analysis. PLos One 2014;9: e94673.

Evangelista A, Gabriele S, Nardinocchi P, Piras P, Puddu PE, Teresi L, Torromeo C, Varano V. On the strain-line pattern in the real human left ventricle. J Biomechanics 2014,

Madeo A, Piras P, Evangelista A, Giura G, Dominaci T, Nardinocchi P, Varano V, Chialastri C, Puddu PE, Torromeo C. Unveiling hypertrophic cardiomiopathy mechanics by means of left ventricular morphological trajectroies in 4D. Eur Heart J Cardiovasc Imaging 2014; 15(suppl 2): ii196-ii223.

Madeo A, Piras P, Re F, Gabriele S, Nardinocchi P, Teresi L, Torromeo C, Chialastri C, Schiariti M, Giura G, Evangelista A, Dominici T, Varano V, Zachara E, Puddu PE. A new 4D trajectory-based approach unveils abnormal LV revolution dynamics in hypertrophic cardiomyopathy. Plos One 2014, submitted

Puddu PE, Jouve R, Torresani J, Sambuc R, Jouve A. Prolonged electrical systole in acute myocardial infarction. J Electrocardiol 1980; 13: 337-340.

Puddu PE, Jouve R, Torresani J, Jouve A: QT interval and primary ventricular fibrillation in acute myocardial infarction. Am Heart J 1981; 101: 118-120.

Puddu PE, Bourassa MG, Lespérance J, Hélias J, Danchin N, Goulet C. Can the mode of death be predicted in patients with angiographically documented coronary artery disease? Clin Cardiol 1983; 6: 384‑395.

Kim YH, Lee JH, Hong CK, Cho KW, Park YH, Kim YW, Hwang SY. Heart rate-corrected QT interval predicts mortality in glyphosate-surfactant herbicide-poisoned patients. Am J Emerg Med 2014; 32: 203-207.

Gress S, Lemoine S, Séralini GE, Puddu PE: Glyphosate-based herbicides potently affect cardiovascular system in mammals: review of the literature. Cardiovasc Toxicol 2014 doi: 10.1007/s12012-014-9282-y.

Gress S, Lemoine S, Puddu PE, Séralini GE, Rouet R: Mechanisms involved in the cardiotoxic electrophysiological effects of the herbicide Roundup® in rat and rabbit ventricular myocardium in vitro. Cardiovasc Toxicol 2014 doi:10.1007/s12012-014-9299-2.

Olorunsogo OO. Modification of the transport of protons and Ca2+ ions across mitochondrial coupling membrane by N-(phosphonomethyl)glycine. Toxicology 1990; 61: 205‑209.

De Liz Oliveira Cavalli VL, Cattani D, Heinz Rieg CE, Pierozan P, Zanatta L, Benedetti Parisotto E, Zamoner A.. Roundup disrupts male reproductive functions by triggering calcium-mediated cell death in rat testis and Sertoli cells. Free Rad Biol Med 2013; 65: 335‑346.

Terracciano CM, Miller LW, Yacoub MH. Contemporary use of ventricular assist devices. Annu Rev Med 2010; 61: 255-270.

Wever-Pinzon O, Drakos SG, Kfoury AG, Nativi JN, Gilbert EM, Everitt M, Alharethi R, Brunisholz K, Bader FM, Li DY, Selzman CH, Stehlik J. Morbidity and mortality in heart transplant candidates supported with mechanical circulatory support: is reappraisal of the current United network for organ sharing thoracic organ allocation policy justified? Circulation 2013; 127: 452-462.

Frazier OH, Benedict CR, Radovancevic B, Bick RJ, Capek P, Springer WE, Macris MP, Delgado R, Buja LM. Improved left ventricular function after chronic left ventricular unloading. Ann Thorac Surg 1996; 62: 675-681.

Soppa GK, Barton PJ, Terracciano CM, Yacoub MH. Left ventricular assist device-induced molecular changes in the failing myocardium. Curr Opin Cardiol 2008; 23: 206-218.

Ibrahim M, Terracciano CM, Yacoub MH. Bridge to recovery: what remains to be discovered? Cardiol Clin 2011; 29: 531-547.

Ibrahim M, Navaratnarajah M, Kukadia P, Rao C, Siedlecka U, Cartledge JE, Soppa GK, Van DC, Yacoub MH, Terracciano CM. Heterotopic abdominal heart transplantation in rats for functional studies of ventricular unloading. J Surg Res 2013; 179: e31-39.

Birks EJ. Molecular changes after left ventricular assist device support for heart failure. Circ Res 2013; 113: 777-791.

Drakos SG, Kfoury AG, Stehlik J, Selzman CH, Reid BB, Terrovitis JV, Nanas JN, Li DY. Bridge to recovery: understanding the disconnect between clinical and biological outcomes. Circulation 2012; 126: 230-241.

Terracciano CM, Hardy JP, Birks EJ, Khaghani A, Banner NR, Yacoub MH. Clinical recovery from end-stage heart failure using left-ventricular assist device and pharmacological therapy correlates with increased sarcoplasmic reticulum calcium content but not with regression of cellular hypertrophy. Circulation 2004; 109: 2263-2265.

Jessup M, Greenberg B, Mancini D, Cappola T, Pauly DF, Jaski B, Yaroshinsky A, Zsebo KM, Dittrich H, Hajjar RJ. Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure. Circulation 2011; 124: 304-313.

Ibrahim M, Al MA, Navaratnarajah M, Siedlecka U, Soppa GK, Moshkov A, bou Al-Saud S, Gorelik J, Yacoub MH, Terracciano CM. Prolonged mechanical unloading affects cardiomyocyte excitation-contraction coupling, transverse-tubule structure, and the cell surface. FASEB J 2010; 24: 3321-3329.

Ibrahim M, Terracciano CM. Reversibility of T-tubule remodelling in heart failure: mechanical load as a dynamic regulator of the T-tubules. Cardiovasc Res 2013; 98: 225-232.

Terracciano CM, Yacoub MH. Heart failure: A SHIFT from ion channels to clinical practice. Nat Rev Cardiol 2010; 7: 669-670.

DiFrancesco D. The role of the funny current in pacemaker activity. Circ Res 2010; 106: 434-446.

Fox K, Ford I, Steg PG, Tendera M, Ferrari R. Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial. Lancet 2008; 372: 807-816.

Swedberg K, Komajda M, Bohm M, Borer JS, Ford I, Dubost-Brama A, Lerebours G, Tavazzi L. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet 2010; 376: 875-885.

Fox K, Ford I, Steg PG, Tardif JC, Tendera M, Ferrari R. Ivabradine in stable coronary artery disease without clinical heart failure. N Engl J Med 2014; 371: 1091-1099.

Tardif JC, O'Meara E, Komajda M, Bohm M, Borer JS, Ford I, Tavazzi L, Swedberg K. Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiography substudy. Eur Heart J 2011; 32: 2507-2515.

Cerbai E, Barbieri M, Mugelli A. Characterization of the hyperpolarization-activated current, I(f), in ventricular myocytes isolated from hypertensive rats. J Physiol 1994; 481 (Pt 3): 585-591.

Navaratnarajah M, Ibrahim M, Siedlecka U, Van DC, Shah A, Gandhi A, Dias P, Sarathchandra P, Yacoub MH, Terracciano CM. Influence of ivabradine on reverse remodelling during mechanical unloading. Cardiovasc Res 2013; 97: 230-239.

Puddu PE, Menotti A, Tolonen H, Nedeljkovic S, Kafatos A:.Determinants of 40-year all-cause mortality in the European cohorts of the Seven Countries Study. Eur J Epidemiol 2011; 26: 595-608.

Lanti M, Puddu PE, Menotti A. Voltage criteria of left ventricular hypertrophy in sudden and nonsudden coronary artery disease mortality: the italian section of the Seven Countries Study. Am J Cardiol 1990; 66: 1181-1185.

Okwuosa TM, Soliman EZ, Lopez F, Williams KA, Alonso A, Ferdinand KC. Left ventricular hypertrophy and cardiovascular disease risk prediction and reclassification in blacks and whites: The Atherosclerosis Risk in Communities Study. Am Heart J 2015;169:155-161.

Lamata P, Casero R, Carapella V, Niederer SA, Bishop MJ, Schneider JE, Kohl P, Grau V. Images as drivers of progress in cardiac computational modelling. Progr Biophys Mol Biol 2014; 115; 198-212.

Lieb W, Gona P, Larson MG, Aragam J, Zile MR, Cheng S, Benjamin EJ, Vasan RS. The natural history of left ventricular geometry in the community. Clinical correlates and prognostic signiï¬cance of change in LV geometric pattern. J Am Coll Cardiol Img 2014;7:870–8






Translational Cardiology