Use of Human Embryonic Stem Cells in the Treatment of Thrombocytopenia: A Case Series: hESC therapy in Thrombocytopenia
Background: Treatment options such as corticosteroids, immunog- lobulins medicines, blood or platelet transfusions, or splenectomy are used for thrombocytopenia patients. In the present study, we reported the safety and efficacy of human embryonic stem cell (hESC) therapy in two patients with thrombocytopenia. The patients were presented with general weakness, and were unable to do their routine work. After the laboratory examinations, it was confirmed that both the patients were suffering from thrombocytopenia having platelet count 0.70m3 and 0.80m3, respectively.
Methods and Findings: hESCs used in the present study were ob- tained from a single, spare, expendable, pre-implantation stage fertili- zed ovum taken during natural in vitro fertilization (IVF) and free from immunogenicity. After a single treatment session with hESCs, both patients showed an increase in blood platelet count and improvement in their condition. No adverse events (AEs) were reported.
Conclusions: hESC therapy was found to be safe and effective. The study concluded that hESC therapy improved the condition of patients with thrombocytopenia.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under aÂ Creative Commons Attribution LicenseÂ that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open AccessÂ and Benefits of Publishing Open Access).