The The effect of High Dose of Vitamin D3 on the Prognosis of Patients with Multiple Sclerosis

Authors

  • Ledjane Neves de Oliveira Federal University of São Carlos
  • Conceição Walsimary Justa Uchoa Federal University of São Carlos
  • Eliane da Silva Grazziano Federal University of Sao Carlos
  • Regimar Carla Machado Federal University of Sao Carlos

DOI:

https://doi.org/10.3823/2170

Abstract

Introduction. Multiple Sclerosis is a chronic inflammatory neurodegenerative disease of large magnitude in the world.

Method and Goal. To analyze primary studies associating high dose of vitamin D with the prognosis of patients with multiple sclerosis.

Results. 9 studies were selected, including 1022 participants. 630 of them were randomized to vitamin D3 supplementation in high dose, 171 in low-dose and 221 receiving placebo.

Conclusion. There is evidence that high dose of Vitamin D3 provide immunomodulatory effects in patients with Multiple Sclerosis, showing improvement in the patients' prognosis.

Author Biographies

Ledjane Neves de Oliveira, Federal University of São Carlos

Nurse graduated by the Faculty of Medicine of Marília (Famema).

Conceição Walsimary Justa Uchoa, Federal University of São Carlos

Nurse at the Emergency Unit of the City of San Carlos.

Eliane da Silva Grazziano, Federal University of Sao Carlos

Nurse. Doctorate in Nursing (EEUSP, São Paulo). Professor of the Nursing Department of the Federal University of São Carlos (UFSCar), São Carlos, SP, Brazil. 

Regimar Carla Machado, Federal University of Sao Carlos

Nurse. Cardiovascular Surgery Dr. (UNIFESP, São Paulo); Professor of the Nursing Department of the Federal University of São Carlos (UFSCar), São Carlos, SP, Brazil. 

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Published

2016-11-05

Issue

Section

Neurology

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