Evidence for Dry Eye Treatment in Hematopoietic Stem Cells Post-Transplantation


  • Isabelle Campos de Azevedo Federal University of Rio Grande do Norte
  • Jéssica Naiara de Medeiros Araújo
  • Isabelle Katherinne Fernandes Costa
  • Alexsandra Rodrigues Feijão
  • Rita de Cássia Lira da Silva
  • Jéssica de Araújo Olímpio
  • Priscila Fernandes Meireles Câmara
  • Hanna Priscila da Silva
  • Jéssica Valeska Herculano Lima
  • Danielly Oliveira Pitombeira
  • Allyne Fortes Vitor
  • Marcos Antonio Ferreira Júnior




Hematopoietic Stem Cell Transplantation, Bone Marrow Transplantation, Graft vs. host disease, Keratoconjunctivitis Sicca, Dry Eye Syndromes


Introduction: Hematopoietic Stem Cell Transplantation (HSCT) is a treatment modality for oncology and hematological diseases genetically inherited or acquired. The morbidities and mortalities related to HSCT are evident in its different phases, such as the Graft Versus Host Disease especially on dry eye syndrome, one of the most complication of chronic phase, characterized as a multifactorial disease of the ocular surface. Several treatments may be directed to the dry eye and the consequences caused by it during the HSCT post-period.

Objective: To reveal the treatments for dry eye in patients after HSCT period.

Method: This is a literature integrative review performed by the SCOPUS databases, National Library of Medicine (PubMed); Web of Science and Cumulative Index to Nursing and Allied Heath Literature (CINAHL).

Results: Of the 1,551 articles identified, there were 21 in the final sample. Regarding the treatments addressed, the most often used was found the cyclosporine 0.05%, followed by allogeneic and autologous drops.

Conclusion: There was no consensus identified as the best type of treatment for these patients. However, it is known that depend mainly on clinical features of chronic graft-versus-host eye on the post-transplantation situation.

Author Biography

Isabelle Campos de Azevedo, Federal University of Rio Grande do Norte

Nurse. Master's Student in Post-Graduate Program in Nursing of the Federal University of Rio Grande do Norte. Natal/RN, Brazil.


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