Y-chromosome Microdeletion and Male Infertility: a Systematic Review
DOI:
https://doi.org/10.3823/1788Keywords:
Y-Chromosome, Infertility, Microdeletion, Male InfertilityAbstract
Objective: evaluate the current evidence regarding different aspects (Epidemiological, histological, physiological and genetic) of male infertility caused by Y-chromosome microdeletion.
Material and Methods: A systematic review of articles from January 1st, 1996 and February 28th, 2014 present in two databases: MEDLINE and SciELO. The search was performed with the MeSH descriptors "Y Chromosome", "Infertility†and Keyword "microdeletion".Â
Results: The literature indicates that deletion of AZF, especially AZFc, is related to azoospermia, oligozoospermia or even infertility. The absence of other loci is also underlined by the evidence: AZFa, AZFb and AZFd, even though the prevalence rates are not equidistant. Surveys also show changes in the male hormone physiology varying the levels of testosterone/LH/FSH as well as modifying the gonadal morphology in individuals affected by Y-chromosome microdeletion.
Conclusion: More research is needed focusing on possible deletions that the Y-chromosome may suffer, giving emphasis on their clinical outcomes and correlations with infertility.
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