Hepatitis B Virus and 2 Î²-Microglobulin Concentration in Individuals Living with Human Immune Deficiency Virus in South West Nigeria
Keywords:2Î²Microglobulin, Hepatitis B virus, HIV, ELISA, Co-infection, Mono-infection
Hepatitis B virus (HBV) is a major health concern with people leaving with HIV/AIDS. However, not much have associated HBV with increase in 2Î²-microglobulin (2Î²M) concentration in people living with HIV/AIDS in sub-saharan Africa though is a tumor marker.
Materials and Methods
Blood sample (n=435) were collected from individuals attending various HIV screening centres in South west Nigeria after the exclusion of individuals testing positive to tuberculosis, Hepatitis C virus (HCV), Human papilloma virus (HPV), (all tested by ELISA technique) typhoid and malaria. Of the 435 individuals selected for the study, 110 were positive for HIV alone, 217 for HIV and HBV while 108 were mono-infected with HBV. All individuals were tested for 2MG using the quantitative ELISA technique.
There was a significant increase in 2MG concentration among those infected with HIV and HBV as opposed to the low levels in mono-infected individuals when compared to the normal concentration of 2Î²M in healthy individuals. Â Â
The elevated level of 2Î²M in HIV coinfection with HBV as compared to the mono-infected individuals and normal concentration, is indicative of the fact that infection with HBV in HIV infected individuals may have caused the elevated 2Î²M in the co-infected individuals. This go to confirm that the risk of developing hepatocellular carcinoma and cirrhosis as well as other related diseases is higher in co-infected individuals. Thereby confirming that HBV is a risk factor to carcinoma in people living with HIV.Â
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