Carbapenem-Resistant Enterobacteriaceae Co-Infections with Klebsiella; a Retrospective Study

Authors

  • Richard A. Giovane St. George's University School of Medicine
  • Steven Brooks

DOI:

https://doi.org/10.3823/1738

Keywords:

Carbapenems, Carbapenem-resistant, Enterobacteriaceae co-infections, Klebsiella, Enterobacteriaceae, KPC-2, KPC-3, OmpF, OmpC, marRAB

Abstract

Abstract:

Background:Carbapenem antibiotics are often used to treat bacterial infections that are refractory to other more commonly used antibiotics. The resilience of bacteria and their resistance mechanisms are of novel interest in the clinical setting, as antibiotic resistant bacteria are posing a challenge to health care professionals. The goal of this retrospective chart review was to isolate Carbapenem resistance among co-infections of Klebsiella and other microorganisms and to conduct a systematic review of this antibiotic resistance.

Methods: This was a retrospective, single center chart review of patients admitted to Kingsbrook Jewish Medical Center from June 2011 to June 2014.

STUDY DESIGN: Retrospective Study, Chart Review

Cases:Two patients met the criteria of the investigators and their charts were reviewed.

Results: Two cases with Klebsiella and E. coli co-infection with Carbapenem-resistant strains  were identified. Patient 1 had a co-infection of Klebsiella and E. coli. Initially, Klebsiella was carbapenem resistant, while E. coli was carbapenem susceptible. However, eventually both bacterial strains developed resistance. Patient 2 had a co-infection of Klebsiella and E. coli which were both carbapenem resistant. However, in contrast to Patient 1, Klebsiella became susceptible to carbapenem. .

Conclusion: The findings indicate that carbapenem-resistant Klebsiella can be transient. Investigation is warranted to exploreinfluence genetic traits, iatrogenic association and environmental causality of CRR. 

Abstract[11] :

Background:Carbapenem antibiotics are often used to treat bacterial infections that are refractory to other more commonly used antibiotics. The resilience of bacteria and their resistance mechanisms are of novel interest in the clinical setting, as antibiotic resistant bacteria are posing a challenge to health care professionals. The goal of this retrospective chart review was to isolate Carbapenem resistance among co-infections of Klebsiella and other microorganisms and to conduct a systematic review of this antibiotic resistance.

Methods: This was a retrospective, single center chart review of patients admitted to Kingsbrook Jewish Medical Center from June 2011 to June 2014.

STUDY DESIGN: Retrospective Study, Chart Review

Cases:Two patients met the criteria of the investigators and their charts were reviewed.

Results: Two cases with Klebsiella and E. coli co-infection with Carbapenem-resistant strains[s2]  were identified. Patient 1 had a co-infection of Klebsiella and E. coli. Initially, Klebsiella was carbapenem resistant, while E. coli was carbapenem susceptible. However, eventually both bacterial strains developed resistance. Patient 2 had a co-infection of Klebsiella and E. coli which were both carbapenem resistant. However, in contrast to Patient 1, Klebsiella became susceptible to carbapenem. .

Conclusion: The findings indicate that carbapenem-resistant Klebsiella can be transient. Investigation is warranted to explore [s3] influence genetic traits, iatrogenic association and environmental causality of CRR. [s4] 

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 [s3]added carbapenem resistant

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References

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Published

2015-06-15

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Section

Infectious Diseases