Epidemiological and clinical factors impact on survival in ALS/ MND: a cohort study

Authors

  • Francis Meire Favero Department of Neurology / Neurosurgery - UNIFESP, São Paulo - SP
  • Mariana Callil Voos PhD, Department of Physical Therapy, Speech and Occupational Therapy, FMUSP, São Paulo - SP
  • Luiz Carlos de Abreu PhD, Department of Health Collective / Scientific Methodology of Discipline - ABC Medical, Santo André-SP
  • Isac de Castro PhD, Department of Nephrology, FMUSP, São Paulo - SP
  • Fátima Aparecida Caromano PhD, Department of Physical Therapy, Speech and Occupational Therapy, FMUSP, São Paulo - SP
  • Abrahão Augusto Juviniano Quadros PhD, Department of Neurology / Neurosurgery - UNIFESP, São Paulo - SP
  • Sissy Veloso Fontes PhD, Department of Neurology / Neurosurgery - UNIFESP, São Paulo - SP
  • Acary Souza Bullé Oliveira MD, PhD, Department of Neurology / Neurosurgery of UNIFESP, São Paulo - SP

Keywords:

epidemiology, amyotrophic lateral sclerosis, motor neuron disease, survival,

Abstract

Background Motor neuron diseases (MND) are rare yet severe neurodegenerative disorders with peculiar characteristics of unknown etiologies that cannot be prevented. They are irreversible and incurable, but treatable diseases. Treatment can improve the quality of life and increase survival. This study aimed to investigate the impact of epidemiological and clinical factors in individuals with motor neuron diseases, particularly amyotrophic lateral sclerosis (ALS). This study aimed to analyse the survival of patients with ALS in relation to clinical and epidemiological aspects. Methods Data were collected from charts in the Division of Clinical Investigation on Neuromuscular Diseases (DCINM), (from 1999 to 2011). Kaplan-Meier curves illustrated the survival time. Results A total of 1146 records of patients with MND were investigated and 578 records, in accordance with the inclusion criteria, were included. For analyzing epidemiological and clinical aspects 231 records were included and survival curves were plotted. Conclusion The survival of patients with MND was not influenced by sex. Younger patients live longer. Too much time passes between initial symptoms and 1st appointment. Patients who survive longest are those who were not diagnosed on the 1st appointment, or did not show any clinical and electromyographic findings, and presented with initial symptoms in the lower limbs

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Published

2015-06-17

Issue

Vol. 8 (2015)

Section

Neurology

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