Inflammatory markers, tbars and vitamin E in class II and III obese patients before undergoing bariatric surgery

Authors

  • Camilla C. C. Radziavicius Faculdade de Medicina do ABC e Universidade Federal de São Paulo (campus Diadema).
  • Fernanda R. C. Radziavicius
  • Edimar C. Pereira
  • Ligia A. Azzalis
  • Paula M. Castelo
  • Virginia B. C. Junqueira
  • Fabíola I. S. Souza
  • Roseli O. S. Sarni
  • Katya C. Rocha
  • Ronaldo B. Oliveira
  • Laura Beatriz Meisiano Maifrino
  • Fernando L. A. Fonseca

DOI:

https://doi.org/10.3823/1667

Keywords:

bariatric surgery, inflammatory markers, obesity, TBARS, vitamin E

Abstract

Background: Obesity and its comorbidities such as insulin resistance, endothelial dysfunction, hypertension, type 2 diabetes and atherosclerosis have been associated with chronic inflammation and oxidative stress. Weight loss with maintenance is not always possible. Bariatric surgery has been proved to be the only efficient method for weight reduction in patients with clinically severe obesity. It leads to significant weight loss and improvement and/or remission of comorbidities. On the other hand, considering that surgical intervention per se induces oxidative stress and inflammatory response, the objective of the present study was to verify if some inflammatory marker, TBARS and/or Vitamin E could be evaluated before gastric surgery. Methods: a quantitative cross-sectional study was carried out at Clinica Ana Rosa (Santo André, SP, Brazil). 100 obese patients (BMI ≥ 35-40 kg/m2) awaiting bariatric surgery were selected for this study. The control group included 29 individuals, BMI < 35 kg/m2, with or without associated comorbidities. The patients completed a structured interview. Weight, height, waist and hip circumferences were also collected. Blood was collected. Glucose (G), total cholesterol (TC), HDL cholesterol (HDLc), LDL cholesterol (LDLc), VLDL cholesterol (VLDLc), triglycerides (TG), high-sensitivity C-reactive protein (hs-CRP), vitamin E (VIT E), fibrinogen (FIB), IL-6 (human interleukin-6), TNF-alpha and thiobarbituric acid reactive substances (TBARS) were measured. Results: patients have shown increased serum levels of hs-CRP and FIB. In this study, class II and III obese patients awaiting bariatric surgery and the control group had lower than normal VIT E levels and no significant changes in TBARS levels were observed. Conclusions: excess weight and accumulated fat in subjects with severe obesity seem to be related to increased inflammatory response, therefore, our results reinforce the importance of evaluating inflammatory markers and VIT E in obese patients before bariatric surgery.

 

Author Biography

Camilla C. C. Radziavicius, Faculdade de Medicina do ABC e Universidade Federal de São Paulo (campus Diadema).

Professor Adjunto III Coordenador do Laboratório de Análises Clínicas

References

Catoi AF, Parvu A, Galea RF, Pop ID, Muresan A, Catoi C. Nitric oxide, oxidant status and antioxidant response in morbidly, obese patients: the impact of 1-year surgical weight loss. Obes Surg 2013; 23:1858-1863.

Lasselin J, Magne E, Beau C, Ledaguenel P, Dexpert S, Aubert A, Layé S, Capuron L. Adipose inflammation in obesity: relationship with circulating levels of inflammatory markers and association with surgery-induced weight loss. J Clin Endrocrinol Metab 2014; 99(1):E53-E61.

Boesin F, Moreira EAM, Wilhelm-Filho D, Vigil SVG, Parizotto EB, Inácio DB, Portari GV, Trindade EBSM, Jordão-Junior AA, Frode TS. Roux-en-Y by-pass gastroplasty: markers of oxidative stress 6 months after surgery. Obes Surg 2010; 20:1236-1244.

Kisakol G, Guney E, Bayraktar F, Yilmaz C, Kabalak T, Ozmen D. Effect of surgical weight loss on free radical and antioxidant balance: a preliminary report. Obes Surg 2002; 12:795-801.

Dadalt C, Fagundes RL, Moreira EA, Wilhelm-Filho D, de Freitas MB, Jordão Júnior AA, Biscaro F, Pedrosa RC, Vannucchi H. Oxidative stress markers in adults 2 years after Roux-en-Y gastric bypass. Eur J Gastroenterol Hepatol. 2013;25(5):580-6. doi: 10.1097/MEG.0b013e32835d0ae0.

Vincent HK, Innes KE, Vincent RF. Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Am J Clin Nutr 2005;82:923-934.

Bullo M, Garcia-Lorda P, Megias I, et al. Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. Obesity Res 2003;11:525-531.

Illán-Gómez F, Gonzálvez-Ortega M, Orea-Soler I, Alcaraz-Tafala MS, Aragón-Alonso A, Pascual-Díaz M, Pérez-Paredes M, Lozano-Almela ML. Obesity and inflammation: change in adiponectin, c-reactive protein, tumor necrosis fator-aplpha and interleukin-6 after bariatric surgery. Obes Res 2012;22:950-955.

Murri M, Garcia-Fuentes E, Garcia-Almeida JM, Garrido-Sanchez L, Mayas MD, Bernal R, Tinahones FJ. Changes in oxidative stress and insuline resistance in morbity obese patients after bariatric surgery. Obes Surg 2010;20:363-368.

Zavala G, Long KZ, Garcia OP, Caãmano M del C, Aguillar T, Salgado LM, Rosado JL. Specific micronutrient concentrations are associated with inflammatory cytokines in a rural population of Mexican women with a high prevalence of obesity. Br J Nutr 2013;109(4):686-94.

Hotamisligil GS. Inflammatory pathways and insulin action. Int J Obesity 2003;27(3):S53-55.

Finer N. Medical consequences of obesity. Medicine (Baltimore). 2006;34(12)510-514.

Costa JV, Duarte JS. Tecido adiposo e adipocinas. Acta Med Port 2006;19(3):251-256.

Rodrigues AS, Trindade EBSM. Mecanismos Neuroendócrinos no Desenvolvimento da Síndrome Metabólica. Rev Bras Nutri Clín 2006;21(4):320-325.

Cabrera EJ, Valezi AC, Delfino VDA, et al. Reduction in plasma levels of inflammatory and oxidative stress indicators after Roux-en-Y gastric bypass. Obesity Surg 2010;20:42-49.

Darvall KAL, Sam RC, Silverman SH, et al. Obesity and Thrombosis. Eur J Vasc Endovasc Surg 2007;33(2):223-233.

Mattar SG, Velcu LM, Rabinovitz M, Demetris AJ, Krasinskas AM, Barinas-Mitchell E, Eid GM, Ramanathan R, Taylor DS, Schauer PR. Surgically-induced weight loss significantly improves nonalcoholic fatty liver disease and the metabolic syndrome. Ann Surg. 2005; 242(4): 610–620.

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Published

2015-04-05

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Section

Laboratory Medicine