Microbiology, diseases, and epidemiology of Kingella kingae in young children: A short review
DOI:
https://doi.org/10.3823/848Keywords:
pharyngeal carriage, Kingella kingae, young childrenAbstract
Kingella kingae is a Gram-negative coccobacilli and it is a member of the HACEK (Haemophilus species, Aggregatibacte actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and K. kingae). HACEK organisms are typically oropharyngeal commensals and have long been recognized as a cause of infective endocarditis in children and adults. K. kingae in difficult to be recovered from cultured pharyngeal samples due to its slow growth and the high presence of resident bacterial flora, however, the organism can be better detected using PCR tests. Based on our search in PubMed and other sources, we couldn't discover any study about K. kingae originated from any Arab country. Therefore, we wrote this review to draw the attention of our physicians and clinical microbiologists on the importance of this neglected group of organisms in clinical medicine. However, this review article aims to cover the most important diseases of K. kingae in the pediatric population.
References
Henriksen SD, Bøvre K. Transfer of Moraxella kingae Henriksen and Bøvre to the genus Kingella gen. nov. in the family Neisseriaceae. International Journal of Systematic and Evolutionary Microbiology. 1976 Oct 1;26(4):447-50. https://www.microbiologyresearch.org/docserver/fulltext/ijsem/26/4/ijs-26-4-447.pdf?expires=1597096411&id=id&accname=guest&checksum=B1209A0EE23C0361F2151B4A5A24D3F0
Stein D C. The Neisseria. The Prokaryotes: Volume 5: Proteobacteria: Alpha and Beta Subclasses, 2006; 602-647.†https://books.google.sm/books?id=sTsC65kCJbUC
Yagupsky P, Porsch E, St Geme JW. Kingella kingae: an emerging pathogen in young children. Pediatrics. 2011 Mar 1;127(3):557-65. https://pediatrics.aappublications.org/content/127/3/557.short
Principi N, Esposito S. Kingella kingae infections in children. BMC infectious diseases. 2015 Dec 1;15(1):260. https://link.springer.com/article/10.1186/s12879-015-0986-9
Cherkaoui A, Ceroni D, Emonet S, Lefevre Y, Schrenzel J. Molecular diagnosis of Kingella kingae osteoarticular infections by specific real-time PCR assay. Journal of medical microbiology. 2009 Jan 1;58(1):65-8. https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.47707-0
Dubnov-Raz G, Ephros M, Garty BZ, et al. Invasive pediatric Kingella kingae infections: a nationwide collaborative study. The Pediatric infectious disease journal. 2010 Jul 1;29(7):639-43. https://journals.lww.com/pidj/Abstract/2010/07000/Invasive_Pediatric_Kingella_kingae_Infections__A.14.aspx
Minamoto GY, Sordillo EM. Kingella denitrificans as a cause of granulomatous disease in a patient with AIDS. Clinical Infectious Diseases. 1992 Dec 1;15(6):1052-3. https://academic.oup.com/cid/article-abstract/15/6/1052/279687
Hassan IJ, Hayek L. Endocarditis caused by Kingella denitrificans. Journal of Infection. 1993 Nov 1;27(3):291-5. https://www.sciencedirect.com/science/article/abs/pii/016344539392213G
Salvo S, Mazón A, Kutz M, Inza E. Vaginitis caused by Kingella denitrificans in a 3-year-old female patient. Enfermedades infecciosas y microbiologia clinica. 1993;11(7):395. https://pubmed.ncbi.nlm.nih.gov/8399481/
Chen C. Distribution of a newly described species, Kingella oralis, in the human oral cavity. Oral microbiology and immunology. 1996 Dec;11(6):425-7. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-302X.1996.tb00206.x?casa_token=-3G1LpQ4yTIAAAAA:EAq8mcPwdGsuwWaXv0S_0d0Gubssj5GAw_qXx5Hw-HHGKV2J1szjyzCiTmo0T6Ly1f7g8pA3iiiT2u6r
Lawson PA, Malnick H, Collins MD, Shah JJ, Chattaway MA, Bendall R, Hartley JW. Description of Kingella potus sp. nov., an organism isolated from a wound caused by ananimal bite. Journal of clinical microbiology. 2005 Jul 1;43(7):3526-9. https://jcm.asm.org/content/43/7/3526.short
Frye SA, Nilsen M, Tønjum T, Ambur OH. Dialects of the DNA uptake sequence in Neisseriaceae. PLoS Genet. 2013 Apr 18;9(4):e1003458. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003458
Kehl-Fie TE, Geme JW. Identification and characterization of an RTX toxin in the emerging pathogen Kingella kingae. Journal of bacteriology. 2007 Jan 15;189(2):430-6. https://jb.asm.org/content/189/2/430.short
Maldonado R, Wei R, Kachlany SC, Kazi M, Balashova NV. Cytotoxic effects of Kingella kingae outer membrane vesicles on human cells. Microbial pathogenesis. 2011 Jul 1;51(12):22-30. https://www.sciencedirect.com/science/article/abs/pii/S088240101100057X
Porsch EA, Kehl-Fie TE, Geme JW. Modulation of Kingella kingae adherence to human epithelial cells by type IV pili, capsule, and a novel trimeric autotransporter. MBio. 2012 Nov1;3(5). https://mbio.asm.org/content/3/5/e00372-12.short
Bendaoud M, Vinogradov E, Balashova NV, Kadouri DE, Kachlany SC, Kaplan JB. Broad-spectrum biofilm inhibition by Kingella kingae exopolysaccharide. Journal of bacteriology. 2011 Aug 1;193(15):3879-86. https://jb.asm.org/content/193/15/3879.short
Starr KF, Porsch EA, Heiss C, Black I, Azadi P, Geme III JW. Characterization of the Kingella kingae polysaccharide capsule and exopolysaccharide. PLoS One. 2013 Sep 30;8(9):e75409. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075409
Valenza G, Ruoff C, Vogel U, Frosch M, Abele-Horn M. Microbiological evaluation of the new VITEK 2 Neisseria-Haemophilus identification card. Journal of clinical microbiology. 2007 Nov 1;45(11):3493-7. https://jcm.asm.org/content/45/11/3493.short
El Houmami N, Durand GA, Bzdrenga J, Darmon A, Minodier P, Seligmann H, Raoult D,Fournier PE. A new highly sensitive and specific real-time PCR assay targeting the malate dehydrogenase gene of Kingella kingae and application to 201 pediatric clinical specimens. Journal of clinical microbiology. 2018 Aug 1;56(8). https://jcm.asm.org/content/56/8/e00505-18.short
Olijve L, Podmore R, Anderson T, Walls T. High rate of oropharyngeal Kingella kingae carriage in New Zealand children. Journal of paediatrics and child health. 2016 Dec;52(12):1081-5. https://onlinelibrary.wiley.com/doi/abs/10.1111/jpc.13287
Yagupsky P. Kingella kingae: carriage, transmission, and disease. Clinical microbiology reviews. 2015 Jan 1;28(1):54-79. https://cmr.asm.org/content/28/1/54.short
Cherkaoui A, Ceroni D, Emonet S, Lefevre Y, Schrenzel J. Molecular diagnosis of Kingella kingae osteoarticular infections by specific real-time PCR assay. Journal of medical microbiology. 2009 Jan 1;58(1):65-8. https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.47707-0
Amit U, Flaishmakher S, Dagan R, Porat N, Yagupsky P. Age-dependent carriage of Kingella kingae in young children and turnover of colonizing strains. Journal of the Pediatric Infectious Diseases Society. 2014 Jun 1;3(2):160-2. https://academic.oup.com/jpids/article/3/2/160/939581
Brändle G, Spyropoulou V, Maggio A, et al. Identifying Reservoirs of Infections Caused by Kingella kingae: A Case–Control Study of Oropharyngeal Carriage of K. kingae Among Healthy Adults. The Pediatric Infectious Disease Journal. 2016 Aug 1;35(8):869-71. https://journals.lww.com/pidj/Abstract/2016/08000/Identifying_Reservoirs_of_Infections_Caused_by.8.aspx
Fournier PE, Rouli L, El Karkouri K, Nguyen TT, Yagupsky P, Raoult D. Genomiccomparison of Kingella kingae strains. Am Soc Microbiol. (2012): 5972-5972. https://jb.asm.org/content/194/21/5972.short
Kampouroglou G, Dubois-Ferrière V, De La Llana RA, Renzi G, Manzano S, Cherkaoui A, Schrenzel J, Ceroni D. A prospective study of intrafamilial oropharyngeal transmission of Kingella kingae. The Pediatric infectious disease journal. 2014 Apr 1;33(4):410-1. https://journals.lww.com/pidj/fulltext/2014/04000/A_Prospective_Study_of_Intrafamilial_Oropharyngeal.23.aspx
El Houmami N, Minodier P, Dubourg G, et al. An outbreak of Kingella kingae infections associated with hand, foot and mouth disease/herpangina virus outbreak in Marseille, France, 2013. The Pediatric Infectious Disease Journal. 2015 Mar 1;34(3):246-50. https://journals.lww.com/pidj/Abstract/2015/03000/An_Outbreak_of_Kingella_kingae_Infections.4.aspx
Chambers ST, Murdoch D, Morris A, et al. HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort. PLoS One. 2013 May 17;8(5):e63181. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063181
Basmaci R. Yagupsky P, Ilharreborde B, et al. Multilocus sequence typing and rtx A toxin gene sequencing analysis of Kingella kingae isolates demonstrates genetic diversity and international clones. PLoS One. 2012 May 31;7(5):e38078. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038078
Slonim A, Steiner M, Yagupsky P. Immune response to invasive Kingella kingae infections, age-related incidence of disease, and levels of antibody to outer-membrane proteins. Clinical infectious diseases. 2003 Aug 15;37(4):521-7. https://academic.oup.com/cid/article/37/4/521/331435
Ambrosioni J, Martinez-Garcia C, Llopis J, et al. HACEK infective endocarditis: Epidemiology, clinical features, and outcome: A case–control study. International Journal of Infectious Diseases. 2018 Nov 1;76:120-5. https://www.sciencedirect.com/science/article/pii/S1201971218345016
Arnold JC, Bradley JS. Osteoarticular infections in children. Infectious Disease Clinics. 2015 Sep 1;29(3):557-74. https://www.id.theclinics.com/article/S0891-5520(15)00061-6/abstract
Brischetto A, Leung G, Marshall CS, Bowen AC. A retrospective case-series of children with bone and joint infection from Northern Australia. Medicine. 2016 Feb;95(8). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779023/
Gravel J, Ceroni D, Lacroix L, et al. Association between oropharyngeal carriage of Kingella kingae and osteoarticular infection in young children: a case–control study. Cmaj. 2017 Sep 5;189(35):E1107-11. https://www.cmaj.ca/content/189/35/E1107.short
Ceroni D, Cherkaoui A, Combescure C, François P, Kaelin A, Schrenzel J. Differentiating osteoarticular infections caused by Kingella kingae from those due to typical pathogens in young children. The Pediatric infectious disease journal. 2011 Oct 1;30(10):906-9. https://journals.lww.com/pidj/fulltext/2011/10000/Differentiating_Osteoarticular_Infections_Caused.24.aspx
.â€Dodwell ER. Osteomyelitis and septic arthritis in children: current concepts. Current opinion in pediatrics. 2013 Feb 1;25(1):58-63. https://journals.lww.com/co-pediatrics/FullText/2013/02000/Osteomyelitis_and_septic_arthritis_in_children__.10.aspx
Ceroni D, Cherkaoui A, Combescure C, et al. Differentiating osteoarticular infections caused by Kingella kingae from those due to typical pathogens in young children. The Pediatric infectious disease journal. 2011 Oct 1;30(10):906-9. https://journals.lww.com/pidj/fulltext/2011/10000/Differentiating_Osteoarticular_Infections_Caused.24.aspx
Ceroni D, Belaieff W,Cherkaoui A, et al. Primary epiphyseal or apophyseal subacute osteomyelitis in the pediatric population: a report of fourteen cases and a systematic review of the literature. JBJS. 2014 Sep 17;96(18):1570-5. https://journals.lww.com/jbjsjournal/Abstract/2014/09170/Primary_Epiphyseal_or_Apophyseal_Subacute.10.aspx
Kiang KM, Ogunmodede F, Juni B, et al. Outbreak of osteomyelitis/septic arthritis caused by Kingella kingae among child care center attendees. Pediatrics. 2005 Aug 1;116(2):e206-13. https://pediatrics.aappublications.org/content/116/2/e206.short
Foster MA, Walls T. High rates of complications following Kingella kingae infective endocarditis in children: a case series and review of the literature. The Pediatric infectious
disease journal. 2014 Jul 1;33(7):785-6. https://journals.lww.com/pidj/Fulltext/2014/07000/High_Rates_of_Complications_Following_Kingella.31.aspx
Bofinger JJ, Fekete T, Samuel R. Bacterial peritonitis caused by Kingella kingae. Journal of clinical microbiology. 2007 Sep 1;45(9):3118-20. https://jcm.asm.org/content/45/9/3118.short
Wolak T, Abu-Shakra, M, Flusser D, et al. Kingella endocarditis and meningitis in a patient with SLE and associated antiphospholipid syndrome. Lupus. 2000 Jun;9(5):393-6. https://journals.sagepub.com/doi/abs/10.1191/096120300678828389?casa_token=JGWImC2-RIAAAAAA%3ArOwKxgbM5cafxszy1TlbmbTcXYo9pcJZyHc9Th86_PeCVSBYchxCR9jWqmJoAqZH6lFB8aI0ZBkrrQ&
Godley DR. Managing musculoskeletal infections in children in the era of increasing bacterial resistance. Journal of the American Academy of PAs. 2015 Apr 1;28(4):24-9. https://journals.lww.com/jaapa/fulltext/2015/04000/Managing_musculoskeletal_infections_in_children_in.4.aspx
Matuschek E, Ã…hman J, Kahlmeter G, Yagupsky P. Antimicrobial susceptibility testing of Kingella kingae with broth microdilution and disk diffusion using EUCAST recommended
media. Clinical Microbiology and Infection. 2018 Apr 1;24(4):396-401. https://www.sciencedirect.com/science/article/pii/S1198743X17304032
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