Impact of the inpatient infectious disease consultations at a tertiary care university hospital

Authors

  • Rami Waked Universite saint Joseph
  • Danielle Jaafar Departement of Infectious Disease, Villeneuve-Saint-Georges, Paris, France
  • Marie Chedid Department of Infectious Diseases, Saint Joseph University, Beirut, Lebanon
  • Gebrael Saliba Department of Infectious Diseases, Saint Joseph University, Beirut, Lebanon
  • Elie Haddad Department of Infectious Diseases, Saint Joseph University, Beirut, Lebanon
  • Jacques Choucair Department of Infectious Diseases, Saint Joseph University, Beirut, Lebanon

DOI:

https://doi.org/10.3823/844

Keywords:

Infectious Disease specialist, Consultation services, Antibiotic stewardship, Antibiotic de-escalation, Impact Assessment, Inpatient treatment

Abstract

BACKGROUND: The role of the infectious disease specialist continues to evolve. The purpose of this study is to demonstrate the value of infectious disease consultation in the inpatient setting.

METHODS: This is a prospective cohort study that took place in a tertiary care university hospital. During the period from April to June 2016, 224 cases of patients receiving antibiotics in the hospital with the request of an infectious diseases’ consultation, were evaluated. The following variables were assessed: the referring department, purpose of the consultation, the antibiotic used before requesting the infectious diseases consultation, the antibiotic modifications after the infectious disease’s visit, whenever the antibiotic usage was switched to a mono or bi-therapy.

RESULTS: The most frequent requesting departments were Oncology (23.2%) and Urology (21.4%). The purpose of the consultations was diagnosis (29%), therapy (41%), both diagnosis and therapy (21%), and prophylaxis (9%). An infectious diseases consultation was given at a rate of 4.9 consultations per 100 hospitalized patients. Antibiotic was discontinued in 14.7% of cases. There was no indication for the antibiotic treatment in 11.6% of cases. Modifying the antibiotic therapy was done in 25.4% of cases. Adjusting the antibiotic dosage was done in only one case. Carbapenem antibiotics were discontinued in 31.6 % of cases and Quinolones discontinuation accounted for 22.7% of cases.

CONCLUSION: Infectious disease consults contributed to the optimization of the diagnostic and therapeutic approaches for suspected or confirmed infections in hospitalized patients.

References

Wernli D, Haustein T, Conly J, Carmeli Y, Kickbusch I, Harbarth

S. A Call for Action: The Application of the International Health

Regulations to the Global Threat of Antimicrobial Resistance.

PLoS Med [Internet]. 2011 Apr 19 [cited 2019 Aug 10];8(4).

Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/

PMC3079636/

WHO|Antimicrobial resistance: global report on surveillance

[Internet]. WHO. [cited 2019 Aug 10]. Available from: http://

www.who.int/drugresistance/documents/surveillancereport/en/

Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice

LB, et al. Bad bugs, no drugs: no ESKAPE! An update from the

Infectious Diseases Society of America. Clin Infect Dis Off Publ

Infect Dis Soc Am 2009;48(1):1–12.

Levy SB, Marshall B. Antibacterial resistance worldwide: causes,

challenges and responses. Nat Med 2004;10(12):S122-129.

Antimicrobial Resistance [Internet]. [cited 2019 Aug 10].

Available from: https://www.idsociety.org/policy--advocacy/

antimicrobial-resistance/

Schuts EC, Hulscher MEJL, Mouton JW, Verduin CM, Stuart

JWTC, Overdiek HWPM, et al. Current evidence on hospital

antimicrobial stewardship objectives: a systematic review and

meta-analysis. Lancet Infect Dis 2016;16(7):847–56.

Dik J-WH, Vemer P, Friedrich AW, Hendrix R, Lo-Ten-Foe JR,

Sinha B, et al. Financial evaluations of antibiotic stewardship

programs—a systematic review. Front Microbiol [Internet]. 2015

Apr 16 [cited 2020 Jun 14];6. Available from: https://www.ncbi.

nlm.nih.gov/pmc/articles/PMC4399335/

Eickhoff TC. Editorial. Whither Infectious Diseases? Some Data

at Last. J Infect Dis 1992;165(2):201–4.

Hamory BH, Hicks LL. Infectious disease manpower in the United

States-1986. 2. Changes in practice patterns over time and

training needs. Manpower and Training Committee, Infectious

Diseases Society of America. J Infect Dis 1992;165(2):218–23.

McGowan JE. The infection control practitioner: An action plan

for the 1990s. Am J Infect Control 1990;18(1):29–39.

Brink AJ, Messina AP, Feldman C, Richards GA, Becker PJ,

Goff DA, et al. Antimicrobial stewardship across 47 South

African hospitals: an implementation study. Lancet Infect Dis.

;16(9):1017–25.

Boyles TH, Whitelaw A, Bamford C, Moodley M, Bonorchis

K, Morris V, et al. Antibiotic Stewardship Ward Rounds and a

Dedicated Prescription Chart Reduce Antibiotic Consumption

and Pharmacy Costs without Affecting Inpatient Mortality or

Re-Admission Rates. PLoS ONE [Internet]. 2013 Dec 9 [cited

Nov 6];8(12). Available from: https://www.ncbi.nlm.nih.

gov/pmc/articles/PMC3857167/

Schlesinger Y, Paltiel O, Yinnon AM. Analysis and impact of

infectious disease consultations in a general hospital. J Hosp

Infect 1998;40(1):39–46.

Yim J, Smith JR, Rybak MJ. Role of Combination Antimicrobial

Therapy for Vancomycin-Resistant Enterococcus faecium

Infections: Review of the Current Evidence. Pharmacother J

Hum Pharmacol Drug Ther 2017;37(5):579–92.

Fernando SA, Gray TJ, Gottlieb T. Healthcare-acquired infections:

prevention strategies. Intern Med J 2017;47(12):1341–51.

Cerceo E, Deitelzweig SB, Sherman BM, Amin AN. Multidrug-

Resistant Gram-Negative Bacterial Infections in the Hospital

Setting: Overview, Implications for Clinical Practice, and Emerging

Treatment Options. Microb Drug Resist 2016;22(5):412–31.

Boyanova L, Mitov I. Antibiotic resistance rates in causative

agents of infections in diabetic patients: rising concerns. Expert

Rev Anti Infect Ther 2013(4):411–20.

Falagas ME, Tansarli GS, Karageorgopoulos DE, Vardakas KZ.

Deaths Attributable to Carbapenem-Resistant Enterobacteriaceae

Infections. Emerg Infect Dis 2014;20(7):1170–5.

Ousaid A, Akrim J, Khayati Y. Overuse of antibiotics as a key

driver to antibiotic resistance in Morocco: A short review with

potential solutions. Int Arab J Antimicrob Agents 2020, May 12

[cited 2020 Jun 14];10(1). Available from: http://imed.pub/ojs/

index.php/ IAJAA/ article/view/2368

Hamze M. Epidemiology and Antibiotic Susceptibility Patterns

of Carbapenem Resistant Gram Negative Bacteria Isolated

from Two Tertiary Care Hospitals in North Lebanon. Int Arab

J Antimicrob Agents [Internet]. 2018 Oct 21 [cited 2020 Jun

;8(2). Available from: http://imed.pub/ojs/index.php/IAJAA/

article/view/2333

Jamal S, Al Atrouni A, Rafei R, Dabboussi F, Hamze M, Osman

M. Molecular mechanisms of antimicrobial resistance in

Acinetobacter baumannii, with a special focus on its epidemiology

in Lebanon. J Glob Antimicrob Resist 2018;15:154–63.

Sexton DJ, Corey GR, Ingram CW, Morris VM, Haywood

HB. Consultation in university-based and community-based

infectious disease practices: a prospective study. Clin Infect Dis

Off Publ Infect Dis Soc Am 1995;20(2):391–3.

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2020-07-05

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