Disseminated Saprochaete capitata in a patient with Diabetes mellitus and HCV Hepatitis; A Case Report
Keywords:Saprochaete capitata, hematological malignancy, yeast, antimicrobials exposure, antifungal resistance.
Saprochaete capitata yeast rarely causes human infections; nonetheless the vast majority of infections were reported in patients with hematological malignancy. Here, we report one of the unusually rare presentations of disseminated Saprochaete capitata in a patient without hematological malignancy, but the patient had a prolonged history of chronic active hepatitis C, diabetes mellitus, prolonged ICU stay on mechanical ventilation, and exposure to several antimicrobials. The currently isolated Saprochaete capitata showed resistance to Amphotericin B, triazoles and ecchinocandins, but susceptible to 5-fluocytocine with MIC â‰¤1 mg/dl.
- Ivannah Pottier, StÃ©phanie Gente, Jean-Paul Vernoux, Micheline GuÃ©guen. Safety assessment of dairy microorganisms: Geotrichum candidum. International Journal of Food Microbiology 2008 September 1;126(3):327â€“332
- S. Mazzocato, E. Marchionni, A. W. Fothergill, D. A. Sutton, S. Staffolani, et al. Epidemiology and outcome of systemic infections due to saprochaete capitata: case report and review of the literature. Infection 2014 July. DOI:10.1007/s15010-014-0668-3
- Villa LÃ³pez I, Doblas Claros A, Saavedra JM, Herrera-Carranza M. Multi-organ failure in a patient with fungaemia due to Saprochaete capitata. Revista Iberoamericana de Micologia 2013;30(4):261-263. DOI: 10.1016/j.riam.2012.12.003
- Juan Carlos GarcÃa-Ruiz, Leyre LÃ³pez-Soria, IÃ±igo OlazÃ¡bal, Elena Amutio, InÃ©s Arrieta-Aguirre, et al. Invasive infections caused by Saprochaete capitata in patients with haematological malignancies: Report of five cases and review of the antifungal therapy. Revista Iberoamericana de MicologÃa MicologÃa 2013 October -Decemebr;30(4):248-255
- Naveen Pemmaraju, Aditya V. Shetty, Victor G. Prieto, Nitin Jain, Dimitrios P. Kontoyiannis and Gautam Borthakur. Disseminated Saprochaete capitata (formerly known as Geotrichum capitatum and Blastoschizomyces capitatus) in a patient with acute myeloid leukemia. European Journal of Haematology 2014 December;93(6):543â€“544
- Muriel Picard, Sophie Cassaing, Philippe Letocart, Xavier Verdeil, Caroline Protin, et al. Concomitant cases of disseminated Geotrichum clavatum infections in patients with acute myeloid leukemia 2014 mBio May;55(5):1186-1188. doi:10.3109/10428194.2013.820290.
- Prashant Purohit, Inam Al-Obaid, Ebtesam Al-Oneizi, Osama Al-Hindi, Leena Joseph, et al. Breakthrough disseminated Saprochaete capitata infection in a child with acute myeloid leukaemia receiving caspofungin therapy. JMM Case Reports 2014. DOI 10.1099/jmmcr.0.001750
- C. Schuermans, M. van Bergen, L. Coorevits, J. Verhaegen, K. Lagrou, et al. Breakthrough Saprochaete capitata infections in patients receiving echinocandins: case report and review of the literature. Med Mycol 2011; 49 (4): 414-418. doi: 10.3109/13693786.2010.535179
- Marisa Z. R. Gomes, Ying Jiang, Victor E. Mulanovich, Russell E. Lewis, Dimitrios P. Kontoyiannisa. Effectiveness of Primary Anti-Aspergillus Prophylaxis during Remission Induction Chemotherapy of Acute Myeloid Leukemia. Antimicrob Agents Chemother 2014 May;58(5):2775â€“2780
- Emilio Bouza, Patricia MuÃ±oz. Epidemiology of candidemia in intensive care units. International Journal of Antimicrobial Agents 2008 November;32:S87â€“S91
- Henry M. Blumberg, William R. Jarvis, J. Michael Soucie, Jack E. Edwards, Jan E. Patterson, et al, and the NEMIS Study Group. Risk Factors for Candidal Bloodstream Infections in Surgical Intensive Care Unit Patients: The NEMIS Prospective Multicenter Study. Clin Infect Dis 2001; 33:177â€“86
- Matthew Morrell, Victoria J. Fraser and Marin H. Kollef. Delaying the Empiric Treatment of Candida Bloodstream Infection until Positive Blood Culture Results Are Obtained: a Potential Risk Factor for Hospital Mortality. Antimicrob. Agents Chemother. 2005 September;49(9): 3640-3645
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