Effects of Veronica Officinalis Extract in the Kidney of Rats with Induced Sepsis*
PURPOSE: To evaluate the effects of Veronica officinalis extract as a anti-inflammatory substance on the kidney function of rats subjected to cecal ligation and puncture, describing histopathological and biochemical findings.
METHODS: Twenty rats (Rattus norvegicus) were distributed into four groups (N=5): Sham group (GS), normal standard animals; Sepsis group (GSep), submitted a cecal ligation and puncture (CLP); Veronica group (GV), administered only Veronica officinalis extract once daily by gavage from the first day until the seventh day, without sepsis induction; Sepsis-Veronica group (GSep-V), administered Veronica officinalis extract once daily by gavage from the first day of CLP until the seventh day procedure. After the euthanasia, blood was collected for assessment of kidney biochemical and histological analysis were performed.
RESULTS: The statistical analysis showed that there was statistically significant in serum levels of creatinine between GS and GSep (p=0.0029); and GSep and GSep-V (p=0.0184). In addition, there was statistically significant of histopathological parameters observed between GS and GSep (p=0.0001); GSep and GV (p=0.0415); also between GSep and GSep-V (p=0.0003).
CONCLUSION: Veronica officinalis extract promoted a significant anti-inflammatory effect on kidney function and reduction of tissue damage in rats with sepsis.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under aÂ Creative Commons Attribution LicenseÂ that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open AccessÂ and Benefits of Publishing Open Access).