Endocrine Disruptors: Bisphenol and Its Relation to Polycystic Ovary Syndrome


  • Watrusy Lima de Oliveira
  • Ruth Figueiredo de Araujo
  • Mariana Carleial Feijó de Sá
  • Gabriel Pinheiro Machado
  • Moisés Martins Araújo
  • Gabriel Pereira Bernardo
  • Italo Cordeiro Moreira
  • Hermes Melo Teixeira Batista Faculdade de Medicina do ABC Hospital Regional do Cariri
  • Sérgio de Araújo
  • Pedro Antônio Gomes Maciel




Endocrine disruptors, Polycystic Ovary Syndrome, Endocrinology


Endocrine disruptors is an issue with great importance toxicological. Among them, there is bisphenol A (BPA) and its possible contributing towards the development of polycystic ovary syndrome (PCOS). Animal studies and cross-sectional models in humans demonstrate the harmful effects from exposure to BPA and drive the need to seek environmentally safe and healthy alternative to the use of BPA.

Author Biography

Hermes Melo Teixeira Batista, Faculdade de Medicina do ABC Hospital Regional do Cariri

departamento de escrita científica da FMABC


OSMAN, A.G.M.; ABOUELFADL, K.Y.; KRUGER, A., KLOAS, W. Screening of multiple hormonal activities in water and sediment from the river Nile, Egypt, using in vitro bioassay and gonadal histology. Environmental Monitoring and Assessment, 2015, 187:317.

ZHAO, J. L., YING, G. G., YANG, B., LIU, S., ZHOU, L. J., CHEN, Z. F., et al. Screening of multiple hormonal activities in surface water and sediment from the Pearl River system, South China, using effect-directed in vitro bioassays. (2011). [Research Support, Non-U.S. Gov't]. Environmental Toxicology and Chemistry / SETAC, 30(10), 2208–2215

BISTAN, M., PODGORELEC, M., LOGAR, R. M., & TISLER, T. Yeast estrogen screen assay as a tool for detecting estrogenic activity in water bodies. (2012). Food Technol Biotech, 50(4), 427–433.

XUE, N., XU, X., & JIN, Z. Screening 31 endocrine-disrupting pesticides in water and surface sediment samples from Beijing Guanting reservoir. (2005). [Research Support, Non-U.S. Gov't]. Chemosphere, 61(11), 1594–1606

SPENGLER, P., KORNER, W., & METZGER, J. W. Substances with estrogenic activity in effluents of sewage treatment plants in southwestern Germany. (2001). 1. Chemical analysis. [Research Support, Non-U.S. Gov't]. Environmental Toxicology and Chemistry / SETAC, 20(10), 2133–2141

CAMPBELL, C. G., BORGLIN, S. E., GREEN, F. B., GRAYSON, A., WOZEI, E., & STRINGFELLOW, W. T. Biologically directed environmental monitoring, fate, and transport of estrogenic endocrine disrupting compounds in water: a review. (2006). [Review]. Chemosphere, 65(8), 1265–1280

Zalko D, Jacques C, Duplan H, Bruel S, Perdu E. Viable skin efficiently absorbs and metabolizes bisphenol A. Chemosphere, 2011, 82:424–30

ELADAK, S.; GRISIN, T.; MOISON, D.; GUERQUIN, M-J.; N’TUMBA-BYN, T.; POZZI-GAUDIN, S.; BENACHI, A.; LIVERA, G.; ROUILLER-FABRE, V.; HABERT, R. A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound. Fertility and Sterility, 2015, 103(1): 11-21.

HUO, X.; CHEN, D.; HE, Y.; ZHU, W.; ZHOU, W.; ZHANG, J. Bisphenol-A and Female Infertility: A Possible Role of Gene-Environment Interactions. International Journal of Environmental Research and Public Health, 2015, 12(9): 11101-11116.

Diamanti-Kandarakis E, Piperi C, Spina J, Argyrakopoulou G, Papanastasiou L, Bergiele A, Panidis D. Polycystic ovary syndrome: the influence of environmental and genetic factors. Hormones (Athens) 2006;5:17–34.

BARRETT, E.S.; SOBOLEWSKI, M. Polycystic ovary syndrome: Do endocrine-disrupting chemicals play a role? Seminars in Reproductive Medicine, 2014, 32(3): 166-176.

PALIOURA, E., KANDARAKI, E., DIAMANTI-KANDARAKIS, E. Endocrine disruptors and polycystic ovary syndrome: a focus on Bisphenol A and its potential pathophysiological aspects. Hormone Molecular Biology and Clinical Investigation, 2014, 17(3): 137-144.







Most read articles by the same author(s)

1 2 > >>