Studies on Survival of Corneal Tissue Transplantation in Patients with Keratoconus
Keywords:Corneal transplantation, Survival analysis, Kaplan-Meier method, Prospective care, Keratoconus
Objective: To analyze the investigations regarding the survival of corneal tissue transplanted into patients affected by keratoconus. Method: This is a review study with the following guiding question: â€œWhat are the factors that influence the survival of transplanted corneal tissue in patients with keratoconus?â€ An integrative review protocol was built for this study to ensure methodological rigor required. The sample selection was through a survey of articles in electronic databases PubMed/MEDLINE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus and Science Direct in October 2014. Indexed descriptors in MeSH and/or synonyms were used: â€œkeratoconusâ€; â€œCorneal transplantationâ€ or â€œkeratoplastyâ€; â€œSurvival analysisâ€ or â€œanalysis of survivalâ€ or â€œmethod Kaplan-Meier.â€ Results: The final sample were thirteen articles available in full in accessible databases. Most of the studies were presented in the retrospective cohort design and used the Kaplan-Meier method for survival analysis. This data varied according to the surgical technique used and the factors that interfere in episodes of rejection postoperatively. Conclusion: The survival of corneal tissue was directly related to the main factors involved in post-transplantation, like rejection, vascular changes, adopted surgical technique and inflammatory processes.
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