Psychiatric Disorders in Prader-Willi Syndrome: a Case Report about Psychotic Symptoms

Authors

  • Marta Herrera Durán Servicio Andaluz de Salud
  • Carlos Gomez Sánchez-Lafuente Servicio Andaluz de Salud
  • Rocío Reina González

DOI:

https://doi.org/10.3823/1809

Keywords:

Prader-Willi, Psychotic symptoms, Hallucinations, Behaviour disorders, Aripiprazole.

Abstract

Background: Psychiatric symptoms are prevalent in patients with Prader-Willi syndrome (PWS), mainly behaviour disorders (temper tantrums and stubbornness) and manipulative behaviour, obsessive-compulsive characteristics in relation with food. True psychosis is evident in young adulthood in approximately 5-10% of patients.

Aim & Objectives: review of psychotic symptoms in patients with a diagnosis of PWS to purpose of a case.

Methods/Study Design: a PWS case report with psychotic symptoms treated with Aripiprazole.

Results/Findings: PWS patients have an increased risk of psychotic disorder or affective illness with a psychotic component, especially young adult patients and those with the maternal uniparental disomy as opposed to paternal deletion.

Conclusion: Behavioural and psychiatric problems interfere the most with quality of life in adulthood. These should be detected early and treated appropriately with parental education and psychotropic medication if it was necessary. Serotonin agonists have been the most successful in reducing temper outbursts and improving compulsivity. Psychosis is treated in a standard manner.

 

 

Author Biographies

Marta Herrera Durán, Servicio Andaluz de Salud

Psychiatrist senior.

Carlos Gomez Sánchez-Lafuente, Servicio Andaluz de Salud

Psychiatry resident

References

Lo ST, Collin PJ, Hokken-Koelega AC. Psychiatric disorders in children with Prader-Willi syndrome-Results of a 2-year longitudinal study. Am J Med Genet A. 2015 May; 167 A(5):983-91.

Larson FV, Whittington J, Webb T, Holland AJ. A longitudinal follow-up study of people with Prader-Willi syndrome with psychosis and those at increased risk of developing psychosis due to genetic subtype. Psychol Med. 2014 Aug; 44(11):2431-5.

Sinnema M, Boer H, Collin P, Maaskant MA, van Roozendaal KE, Schrander-Stumpel CT, Curfs LM. Psychiatric illness in a cohort of adults with Prader-Willi syndrome. Res Dev Disabil. 2011 Sep-Oct; 32(5):1729-35.

Soni S, Whittington J, Holland AJ, Webb T, Maina E, Boer H, Clarke D. The course and outcome of psychiatric illness in people with Prader-Willi syndrome: implications for management and treatment. J Intellect Disabil Res. 2007 Jan; 51(Pt 1):32-42.

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Published

2015-09-23

Issue

Section

International Online Biomedical Conference