Y-chromosome Microdeletion and Male Infertility: a Systematic Review
Keywords:Y-Chromosome, Infertility, Microdeletion, Male Infertility
Objective: evaluate the current evidence regarding different aspectsÂ (Epidemiological, histological, physiological and genetic) of male infertilityÂ caused by Y-chromosome microdeletion.
Material and Methods: A systematic review of articles from JanuaryÂ 1st, 1996 and February 28th, 2014 present in two databases: MEDLINEÂ and SciELO. The search was performed with the MeSH descriptors "YÂ Chromosome", "Infertilityâ€ and Keyword "microdeletion".Â
Results: The literature indicates that deletion of AZF, especially AZFc,Â is related to azoospermia, oligozoospermia or even infertility. The absenceÂ of other loci is also underlined by the evidence: AZFa, AZFb andÂ AZFd, even though the prevalence rates are not equidistant. SurveysÂ also show changes in the male hormone physiology varying the levelsÂ of testosterone/LH/FSH as well as modifying the gonadal morphologyÂ in individuals affected by Y-chromosome microdeletion.
Conclusion: More research is needed focusing on possible deletionsÂ that the Y-chromosome may suffer, giving emphasis on their clinicalÂ outcomes and correlations with infertility.
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