Hepatic Function in Obese Adolescents and the relationship with hepatic steatosis.


  • Regina Maria Banzato
  • Marcelo Rodrigues Bacci
  • Fernando Luiz Affonso Fonseca Faculdade de Medicina do ABC e Universidade Federal de São Paulo (campus Diadema).
  • Carolina G. Bensi
  • Vanessa B. Perestrelo
  • Ethel Zimberg Chehter




obesity, adolescents, hepatic steatosis.


Introduction: The prevalence of obesity has increased at an impressive rate over the past years, especially among children and adolescents. Many are the alterations that may be found in obese individuals; hepatic steatosis is one of them. The aim of this study was to analyze biochemical and radiographic parameters in overweight and obese adolescents and relate these parameters to anthropometric data so that the hepatic dysfunction could be characterized. Methods: Anthropometric and laboratory data, as well as the nutritional status of the patients, were evaluated. Besides laboratory exams, a liver ultrasound scan was performed to confirm hepatic alterations. Results: A total of 41 patients were recruited and 6 out of that total were excluded due to the fact they were eutrophic. The remaining group was compared with a control group of 12 patients. The overweight/obese group had higher values of AST and ALT in relation to the control group. There were no alterations associated with biochemical parameters regarding anthropometric variables. A significant difference between the BMI of patients with and without steatosis could be observed. Conclusions: There was a predominance of hepatic steatosis in the overweight/obese group, which was associated with the increase in GGT and ALT levels.

Author Biography

Fernando Luiz Affonso Fonseca, Faculdade de Medicina do ABC e Universidade Federal de São Paulo (campus Diadema).

Professor Adjunto III Coordenador do Laboratório de Análises Clínicas


Ogden CL,Carroll MD, Kit BK, Flegal KM. Prevalence of Childhood and Adult Obesity in the United States, 2011-2012. JAMA 2014; 311(8): 806-814.

EnesCC, Slater B. Obesidade na adolescência e seus principais fatores determinantes. Rev Bras Epidemiol 2010; 13(1): 163-7.

Damiani D, Carvalho DP, Oliveira RG. Obesidade na infância um grande desafio! Pediatr Mod 2000; 36 (8): 489-528.

Escrivão MAMS, Oliveira FLC, Taddei JAA C, Lopez FA. Obesidade exógena na infância e na adolescência. J Pediatr 2000; 76 (3): S 305-310.

Muller RCL. Obesidade na adolescência. Ped Mod 2001; 37 (esp).

Mello ED, Luft VC, Meyer F. Obesidade infantile: como podemos ser eficazes? J Ped 2004; 80 (3): 173-82.

Scheen AJ, Luyckx HF. Obesity and liver disease. Best Prctice& Research Clinical Endocrinology and Metabolism 2002: 16 (4): 703-716.

Chituri S, Abeygunasekera S, Farrel GC, Holines-Walker J, Hui JM, Fung C et al. NASH and insulin Resistance: Insulin Hipersecretion and Specific Association with the Insulin Resistance Syndrome. Hepatology 2002; 35: 373-379.

Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, ey al. Nonalcoholic Steatohepatitis: Association of Insulin Resistance and Mitochondrial Abnormalities. Gastroenterology 2001; 120: 1183-1192.

Youssef WI, McCullough AJ. Steatohepatitis in obese individuals. Best Practice& Research Clinical Gastroenterology 2002; 16 (5): 733-747.

Frisancho AR. Antropometric Standards for assesment of growth and nutritional status. Ann Arbor: The University of Michigan Press,1990.

Must A, Dallal GE, Dietz WH. Reference data for obesity: 85th and 95th percentiles of body mass index ( wt/ht2) – a correctio9n. Am J Clin Nutr 1991; 53: 839-46.

Saverymutu SH, Joseph AEA, Maxwell JD. Ultrasound scanning in the detection of hepatic fibrosis and steatosis. BMJ 1986; 292: 13-5.

Silva GAP, Balaban G, Nascimento EMM,Baracho JDS, Freitas MMV. Prevalência de sobrepeso e obesidade em adolescentes de uma escola pública em Recife. Rev bras saúde matern infant 2002; 2 (1): 37-42.

Huang YC, Wu JY, Yang MJ. Weight-forheight reference and the prevalence of obesity for school children and adolecents in Taiwán and Fuchien Areas. J Chin Med Assoc 2003; 66 (10): 599-606.

Asayama K, Hayashibe H, Dobashi K, Uchida N, Nakane T, Kodera K et al. Increased serum cholesterol ester transfer protein in obese children Obes Res 2002; 10 (6): 439-46.

Csábi G, Torok K, Jeges S, Moenar D. Molnár D. Presence of metabolic cardiovascular sybdrome in obese children. Eur J Pediatr 2000; 159: 91-94.

Chan MH, Wong EM, Liu EK et al. Hepatitic steatosis in obese Chinese children. Int J Obes Relat Metab Disord 2004; 28 (10): 1257-63.

Shimada M, Hashimoto E, Kaneda H, Noguchi S, Hayashi N. Nonalcoholic steatohepatitis: risk factors for live fibrosis. Hepatology Research 2002; 24: 429-438.

Nehra V, Angulo P, Buchman AL, Lindor KD. Nutritional and Metabolic Considerations in the Etiology of Nonalcoholicsteatohepatitis. Digestive Diseases and Science 2001; 46 ( 11): 2347-2352.

Moleston JP, White F, Teckman J, Fitzgerald JF. Obese Children With Seatohepatitis Can Develop Cirrhosis in Childhood. Am J Gastroenterol 2002; 97 (9): 2460-2462.

Feldstein AE, Canbay A, Angulo P, Yaniai M, Burgart LJ, Lindor KD et al. Hepatocyte Apoptosis and Fas expression Are Prominent features of Human Nonalcoholic Steatohepatitis. Gastroenterology 2003; 125: 437-443.

Teske M, Melges AP, Souza FI, Fonseca FL, Sarni RO. Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome components. Revista Paulista de Pediatria (Impresso), v. 32, p. 50-54, 2014.

Souza F, Amancio OM, Sarni RO, Pitta TS, Fernandes AP, Fonseca FL, Hix S, Ramalho A. Non-alcoholic Fatty disease in overweight children and its relationship with retinol serum levels. International Journal for Vitamin and Nutrition Research, v. 78, p. 27-32, 2008.






Laboratory Medicine

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