Heart Rate Variability During Hemodialysis in Patients with Chronic Renal Disease


  • Sidney Benedito Silva
  • Vitor E Valenti
  • Fernando Adami
  • Elisa Rennó Dester
  • Fernando de Souza Almeida
  • Iara Gracia Lorena
  • David . M Garner
  • Rodrigo Daminello Raimundo Scientific Writing Laboratory, Faculty of Medicine of ABC, Santo Andre, SP, Brazil
  • Rayana L. Gomes
  • Ronaldo Roberto Bergamo
  • Tatiana Dias de Carvalho
  • Luiz Carlos de Abreu




Autonomic nervous system, Cardiovascular system, Physiology, Renal dialysis.


Background: Few studies evaluated cardiac autonomic responses induced by hemodialysis. We aimed to evaluate cardiac autonomic regulation during hemodialysis in haemodynamically stable patients with chronic renal disease. Method: Heart rate variability (HRV) was analyzed in the time and frequency domains in the following periods: Pre-dialysis (10 minutes before); Hemodialysis (240 minutes). Results: The standard deviation of all normal RR intervals (SDNN) increased 60-90min after hemodialysis compared to pre-hemodialysis (29.77 ± 12ms vs. 51.70 ± 41.6ms - p<0.05). The percentage of adjacent RR intervals with a difference of duration greater than 50ms (pNN50) also raised 180-210 min after hemodialysis compared to 0-30 min after hemodialysis (1.29 ± 3.5 vs. 4.37 ± 7.8 - p<0.05). Low frequency (LF) (ms2) increased 150-180 min after hemodialysis compared to pre-hemodialysis (168.2±179.8 ms2 vs. 562.6±455.7 ms2: p<0.05) and high frequency (HF) (ms2) band raised 150-180min and 180-210 after hemodialysis compared to pre-hemodialysis (59.3 ± 70.78ms2 vs. 212.5 ± 304.9 ms2 vs. 186.3 ± 335.1 ms2: p<0.05). Conclusion: Hemodialysis acutely increased HRV, raising the parasympathetic component of  HRV.


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